Protective Roles of Quercetin, Vitamin C and Pyridoxine on Lead Neurotoxicity via Enhanced Haematopoietic and Antioxidants Components

Abstract

Background: The harmful effects of lead exposure, especially its effect on the nervous system, raise serious concerns worldwide. This study is aimed at evaluating the effect of Quercetin, Vitamin C and Pyridoxine on Haematology, biochemical and histology of the cerebral cortex on lead induced neurotoxicity using adult Wistar rat models. Materials and Methods: Forty male Wistar albino rats were divided into five groups: control, lead only, lead + Quercetin, lead + Pyridoxine, lead and Vitamin C. 100mg/kg/bw of lead was used to induce-toxicity for 7 days and treated with the following: Quercetin, Pyridoxine and Vitamin C were administrated orally respectively for 14 days. Hematological and biochemical samples were collected in three phases. The cerebral cortex was examined under light microscopy after H&E staining. Results: lead decreased all hematological parameters (PCV, WBC, RBC, HB and Platelets) examined and in the biochemical parameters, decreased slightly SOD, increased MDA and reduced significantly (p values) GSH. Quercetin, Vitamin C and Pyridoxine had strong curative effects on both hematological and biochemical parameters. On the histology, lead revealed mild glial cell infiltration. All treatment groups showed normal neuronal cells. Conclusion: Quercetin, Vitamin C and Pyridoxine showed neuroprotective effects against lead-induced neurotoxicity; therefore, they can be used as routine supplements against lead toxicity in endemic communities.